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KMID : 1145520200060010046
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Journal of Radiopharmaceuticals and Molecular Probes
2020 Volume.6 No. 1 p.46 ~ p.52
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Consideration and factors for developing new radiopharmaceuticals
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Kim Dong-Wook
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Abstract
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Radiopharmaceuticals that can be consumed in specific disease site play a key role In order to diagnose and treat the diseases. In addition, radiopharmaceuticals can be used for diagnostic or therapeutic purposes depending on the type of the labeled radioactive isotope. Recently, theragnostic radiopharmaceuticals that can simultaneously diagnose and treat are developed. Therefore, the development of target-specific radiopharmaceuticals is a very important research topic in the field of molecular imaging and therapy. This review paper summarizes the basic considerations for the development of radiopharmaceuticals. For new researchers or students who are now beginning in the field of radiopharmaceuticals, we intend to assist in the development of radiopharmaceuticals by describing the definition of radiopharmaceuticals, the ideal radiopharmaceutical conditions, the considerations for developing new radiopharmaceuticals, the factors affecting the design of radiopharmaceuticals, the requirements of radioisotope labeling reactions, and finally the definition and importance of molar activity in radiopharmaceuticals.
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KEYWORD
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Radiopharmaceuticals, Radiolabeling, Molecular imaging, Radioisotope, Positron emission tomography
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